Assay Detail
Binding
CHEMBL842020
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of p56 Lck tyrosine kinase, in presence of 1 mM ATP
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.40 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69068 | — | — | 1 | 8.52 |
| CHEMBL307982 | — | — | 1 | 7.96 |
| CHEMBL47940 | — | — | 1 | 7.80 |
| CHEMBL302481 | — | — | 1 | 7.52 |
| CHEMBL68888 | — | — | 1 | 7.16 |
| CHEMBL302281 | — | — | 1 | 7.12 |
| CHEMBL66716 | — | — | 1 | 7.12 |
| CHEMBL302279 | — | — | 1 | 6.54 |
| CHEMBL68430 | — | — | 1 | 6.42 |
| CHEMBL71722 | — | — | 1 | 6.34 |
| CHEMBL71541 | — | — | 1 | 6.28 |
| CHEMBL67268 | — | — | 1 | 6.20 |
| CHEMBL70034 | — | — | 1 | 6.12 |
| CHEMBL304113 | — | — | 1 | 6.10 |
| CHEMBL303195 | — | — | 1 | 6.00 |
| CHEMBL305748 | — | — | 1 | 5.97 |
| CHEMBL68773 | — | — | 1 | 5.88 |
| CHEMBL66102 | — | — | 1 | 5.68 |
| CHEMBL68082 | — | — | 1 | 5.51 |
| CHEMBL71985 | — | — | 1 | 5.26 |
| CHEMBL67211 | — | — | 1 | 4.80 |
| CHEMBL67598 | — | — | 1 | 4.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69068 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL307982 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL47940 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL302481 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL68888 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL302281 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL66716 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL302279 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL68430 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL71722 | — | IC50 | = | 459.0 | nM | 6.34 |
| CHEMBL71541 | — | IC50 | = | 529.0 | nM | 6.28 |
| CHEMBL67268 | — | IC50 | = | 633.0 | nM | 6.20 |
| CHEMBL70034 | — | IC50 | = | 751.0 | nM | 6.12 |
| CHEMBL304113 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL303195 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL305748 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL68773 | — | IC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL66102 | — | IC50 | = | 2110.0 | nM | 5.68 |
| CHEMBL68082 | — | IC50 | = | 3090.0 | nM | 5.51 |
| CHEMBL71985 | — | IC50 | = | 5550.0 | nM | 5.26 |
| CHEMBL67211 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL67598 | — | IC50 | = | 26200.0 | nM | 4.58 |