Assay Detail
Binding
CHEMBL842012
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of p56 Lck tyrosine kinase (catalytic domain), in presence of 1 mM ATP
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.00 | 5.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL47940 | — | — | 1 | 5.97 |
| CHEMBL71722 | — | — | 1 | 5.60 |
| CHEMBL67268 | — | — | 1 | 5.50 |
| CHEMBL304113 | — | — | 1 | 5.38 |
| CHEMBL66102 | — | — | 1 | 5.15 |
| CHEMBL68430 | — | — | 1 | 5.09 |
| CHEMBL303195 | — | — | 1 | 5.04 |
| CHEMBL71541 | — | — | 1 | 5.00 |
| CHEMBL66716 | — | — | 1 | 4.93 |
| CHEMBL68888 | — | — | 1 | 4.82 |
| CHEMBL70034 | — | — | 1 | 4.79 |
| CHEMBL302279 | — | — | 1 | 4.74 |
| CHEMBL71985 | — | — | 1 | 4.61 |
| CHEMBL68082 | — | — | 1 | 4.60 |
| CHEMBL305748 | — | — | 1 | 4.47 |
| CHEMBL67598 | — | — | 1 | 4.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL47940 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL71722 | — | IC50 | = | 2530.0 | nM | 5.60 |
| CHEMBL67268 | — | IC50 | = | 3130.0 | nM | 5.50 |
| CHEMBL304113 | — | IC50 | = | 4130.0 | nM | 5.38 |
| CHEMBL66102 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL68430 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL303195 | — | IC50 | = | 9120.0 | nM | 5.04 |
| CHEMBL71541 | — | IC50 | = | 10010.0 | nM | 5.00 |
| CHEMBL66716 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL68888 | — | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL70034 | — | IC50 | = | 16040.0 | nM | 4.79 |
| CHEMBL302279 | — | IC50 | = | 18300.0 | nM | 4.74 |
| CHEMBL71985 | — | IC50 | = | 24800.0 | nM | 4.61 |
| CHEMBL68082 | — | IC50 | = | 25100.0 | nM | 4.60 |
| CHEMBL305748 | — | IC50 | = | 33500.0 | nM | 4.47 |
| CHEMBL67598 | — | IC50 | = | 43200.0 | nM | 4.37 |