Assay Detail
Binding
CHEMBL847683
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Inhibitory activity against tie-2 at a concentration of 5 uM ATP.
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 6.06 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL68082 | — | — | 1 | 6.89 |
| CHEMBL71541 | — | — | 1 | 6.79 |
| CHEMBL71722 | — | — | 1 | 6.62 |
| CHEMBL70034 | — | — | 1 | 6.61 |
| CHEMBL302279 | — | — | 1 | 6.44 |
| CHEMBL303195 | — | — | 1 | 6.40 |
| CHEMBL305748 | — | — | 1 | 6.39 |
| CHEMBL307982 | — | — | 1 | 6.37 |
| CHEMBL68773 | — | — | 1 | 6.37 |
| CHEMBL68888 | — | — | 1 | 6.30 |
| CHEMBL67268 | — | — | 1 | 6.25 |
| CHEMBL67598 | — | — | 1 | 6.24 |
| CHEMBL66102 | — | — | 1 | 6.22 |
| CHEMBL67560 | — | — | 1 | 6.21 |
| CHEMBL67211 | — | — | 1 | 6.17 |
| CHEMBL69068 | — | — | 1 | 6.05 |
| CHEMBL71985 | — | — | 1 | 6.01 |
| CHEMBL68663 | — | — | 1 | 5.99 |
| CHEMBL69649 | — | — | 1 | 5.91 |
| CHEMBL433097 | — | — | 1 | 5.82 |
| CHEMBL302481 | — | — | 1 | 5.75 |
| CHEMBL69868 | — | — | 1 | 5.74 |
| CHEMBL304113 | — | — | 1 | 5.72 |
| CHEMBL47940 | — | — | 1 | 5.70 |
| CHEMBL69544 | — | — | 1 | 5.65 |
| CHEMBL302281 | — | — | 1 | 5.57 |
| CHEMBL66716 | — | — | 1 | 4.96 |
| CHEMBL68430 | — | — | 1 | 4.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL68082 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL71541 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL71722 | — | IC50 | = | 239.0 | nM | 6.62 |
| CHEMBL70034 | — | IC50 | = | 246.0 | nM | 6.61 |
| CHEMBL302279 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL303195 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL305748 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL307982 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL68773 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL68888 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL67268 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL67598 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL66102 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL67560 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL67211 | — | IC50 | = | 677.0 | nM | 6.17 |
| CHEMBL69068 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL71985 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL68663 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL69649 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL433097 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL302481 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL69868 | — | IC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL304113 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL47940 | — | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL69544 | — | IC50 | = | 2260.0 | nM | 5.65 |
| CHEMBL302281 | — | IC50 | = | 2680.0 | nM | 5.57 |
| CHEMBL66716 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL68430 | — | IC50 | = | 23400.0 | nM | 4.63 |