Assay Detail
Binding
CHEMBL818103
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Inhibitory activity against human platelet microsomal TXA2 synthase
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Thromboxane modulating agents. 2. Thromboxane receptor antagonists derived from the thromboxane synthase inhibitor dazmegrel.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.52 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL45075 | — | — | 1 | 7.72 |
| CHEMBL283656 | DAZMEGREL | 2.0 | 1 | 7.55 |
| CHEMBL295512 | — | — | 1 | 7.47 |
| CHEMBL47612 | — | — | 1 | 7.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL45075 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL283656 | DAZMEGREL | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL295512 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL47612 | — | IC50 | = | 48.0 | nM | 7.32 |