Assay Detail
Binding
CHEMBL818108
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Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Stepwise modulation of neurokinin-3 and neurokinin-2 receptor affinity and selectivity in quinoline tachykinin receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 8.06 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL47739 | — | — | 1 | 9.22 |
| CHEMBL47775 | — | — | 1 | 9.15 |
| CHEMBL45129 | — | — | 1 | 9.10 |
| CHEMBL295770 | — | — | 1 | 9.00 |
| CHEMBL45961 | — | — | 1 | 8.92 |
| CHEMBL296857 | — | — | 1 | 8.82 |
| CHEMBL33868 | — | — | 1 | 8.80 |
| CHEMBL47412 | — | — | 1 | 8.62 |
| CHEMBL45362 | — | — | 1 | 8.38 |
| CHEMBL47544 | — | — | 1 | 8.34 |
| CHEMBL47713 | — | — | 1 | 8.24 |
| CHEMBL47179 | — | — | 1 | 8.21 |
| CHEMBL296122 | — | — | 1 | 8.04 |
| CHEMBL297086 | — | — | 1 | 7.73 |
| CHEMBL47408 | — | — | 1 | 7.65 |
| CHEMBL432301 | — | — | 1 | 7.48 |
| CHEMBL295059 | — | — | 1 | 7.29 |
| CHEMBL10188 | TALNETANT | 2.0 | 1 | 6.84 |
| CHEMBL44722 | — | — | 1 | 6.76 |
| CHEMBL47275 | — | — | 1 | 6.56 |
| CHEMBL47555 | — | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL47739 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL47775 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL45129 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL295770 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL45961 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL296857 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL33868 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL47412 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL45362 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL47544 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL47713 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL47179 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL296122 | — | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL297086 | — | Ki | = | 18.5 | nM | 7.73 |
| CHEMBL47408 | — | Ki | = | 22.2 | nM | 7.65 |
| CHEMBL432301 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL295059 | — | Ki | = | 51.6 | nM | 7.29 |
| CHEMBL10188 | TALNETANT | Ki | = | 144.0 | nM | 6.84 |
| CHEMBL44722 | — | Ki | = | 172.0 | nM | 6.76 |
| CHEMBL47275 | — | Ki | = | 276.0 | nM | 6.56 |
| CHEMBL47555 | — | Ki | = | 811.0 | nM | 6.09 |