Assay Detail
Binding
CHEMBL818205
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Concentration of compound required for 50% inhibition of type III cAMP phosphodiesterase from dog ventricles, activity expressed as pIC50
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological properties of BW315c and other inotropic 2-arylimidazo[1,2-a]pyrazines
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.55 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL43072 | — | — | 1 | 5.00 |
| CHEMBL2110680 | ISOMAZOLE | 2.0 | 1 | 4.50 |
| CHEMBL148506 | — | — | 1 | 4.40 |
| CHEMBL286020 | SULMAZOLE | 2.0 | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL43072 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2110680 | ISOMAZOLE | IC50 | = | 31622.78 | nM | 4.50 |
| CHEMBL148506 | — | IC50 | = | 39810.72 | nM | 4.40 |
| CHEMBL286020 | SULMAZOLE | IC50 | = | 50118.72 | nM | 4.30 |