Compound Detail
CHEMBL43072
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Basic Information
| ChEMBL ID | CHEMBL43072 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CXWQTCGUKRMZOM-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
287.3
MW (Da)
2.14
ALogP
5
HBA
0
HBD
62.5
PSA (Ų)
0.69
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphodiesterase 3 CHEMBL2094125 | IC50 | 5.0 | 5.0 | 10000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphodiesterase 3 | IC50 | = | 10000.0 | nM | 5.0 | Concentration of compound required for 50% inhibition of type III cAMP phosphodi... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(01)81217-8 | Canis familiaris | 5 |
| - | 10.1016/S0960-894X(01)81217-8 | Cavia porcellus | 1 |
| - | 10.1016/S0960-894X(01)81217-8 | Phosphodiesterase 3 | 1 |
| - | 10.1016/S0960-894X(01)81217-8 | Unchecked | 1 |
| 3397997 | 10.1021/jm00403a018 | Felis catus | 1 |
| 3397997 | 10.1021/jm00403a018 | Canis familiaris | 1 |
Data from ChEMBL 36 via Core Engine