Assay Detail
Functional
CHEMBL818227
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity was determined in the vero cells infected with HIV-I
41
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Asymmetric synthesis and biological evaluation of beta-L-(2R,5S)- and alpha-L-(2R,5R)-1,3-oxathiolane-pyrimidine and -purine nucleosides as potential anti-HIV agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 4.50 | 4.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL57917 | — | — | 1 | 4.70 |
| CHEMBL61181 | — | — | 1 | 4.51 |
| CHEMBL263438 | — | — | 1 | 4.49 |
| CHEMBL293575 | — | — | 1 | 4.31 |
| CHEMBL58544 | — | — | 1 | - |
| CHEMBL141 | LAMIVUDINE | 4.0 | 4 | - |
| CHEMBL885 | EMTRICITABINE | 4.0 | 1 | - |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | - |
| CHEMBL301891 | — | — | 1 | - |
| CHEMBL292175 | — | — | 1 | - |
| CHEMBL299930 | — | — | 1 | - |
| CHEMBL291470 | — | — | 1 | - |
| CHEMBL301886 | — | — | 1 | - |
| CHEMBL58809 | — | — | 1 | - |
| CHEMBL294695 | — | — | 1 | - |
| CHEMBL59576 | — | — | 1 | - |
| CHEMBL300569 | — | — | 1 | - |
| CHEMBL58457 | — | — | 1 | - |
| CHEMBL60981 | — | — | 1 | - |
| CHEMBL300546 | — | — | 1 | - |
| CHEMBL57786 | — | — | 1 | - |
| CHEMBL301042 | — | — | 1 | - |
| CHEMBL60768 | — | — | 1 | - |
| CHEMBL301450 | — | — | 1 | - |
| CHEMBL59553 | — | — | 1 | - |
| CHEMBL418146 | — | — | 1 | - |
| CHEMBL59067 | — | — | 1 | - |
| CHEMBL292358 | — | — | 1 | - |
| CHEMBL294694 | — | — | 1 | - |
| CHEMBL300582 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL57917 | — | IC50 | = | 20200.0 | nM | 4.70 |
| CHEMBL61181 | — | IC50 | = | 31100.0 | nM | 4.51 |
| CHEMBL263438 | — | IC50 | = | 32700.0 | nM | 4.49 |
| CHEMBL293575 | — | IC50 | = | 48500.0 | nM | 4.31 |
| CHEMBL299930 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL57129 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL291470 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL301886 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL58809 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL294695 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL59576 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL300569 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL141 | LAMIVUDINE | IC50 | > | 100000.0 | nM | - |
| CHEMBL292175 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL294694 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL278444 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL60483 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL294690 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL58461 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL141 | LAMIVUDINE | IC50 | > | 100000.0 | nM | - |
| CHEMBL293564 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL61093 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL57786 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL301042 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL141 | LAMIVUDINE | IC50 | > | 100000.0 | nM | - |
| CHEMBL292358 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL141 | LAMIVUDINE | IC50 | > | 100000.0 | nM | - |
| CHEMBL59067 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL418146 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL59553 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL301450 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL60768 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL60858 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL300582 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL300546 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL60981 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL58457 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL58544 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL885 | EMTRICITABINE | IC50 | > | 100000.0 | nM | - |
| CHEMBL129 | ZIDOVUDINE | IC50 | > | 100000.0 | nM | - |
| CHEMBL301891 | — | IC50 | > | 100000.0 | nM | - |