Assay Detail
Binding
CHEMBL818260
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Inhibition of trypsin with benzoyl-L-arginine ethyl ester as substrate
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Inhibition studies of some serine and thiol proteinases by new leupeptin analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.77 | 5.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL191881 | LEUPEPTIN | — | 1 | 5.09 |
| CHEMBL2373046 | — | — | 1 | 5.04 |
| CHEMBL2373041 | — | — | 1 | 4.92 |
| CHEMBL2373060 | — | — | 1 | 4.43 |
| CHEMBL2373045 | — | — | 1 | 4.35 |
| CHEMBL2373062 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL191881 | LEUPEPTIN | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL2373046 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL2373041 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL2373060 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL2373045 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL2373062 | — | IC50 | = | 130000.0 | nM | - |