Assay Detail
Binding
CHEMBL818267
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Concentration of compound required to inhibit 50% trypsin derived from bovine pancreas
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
2-amino-4H-3,1-benzoxazin-4-ones as inhibitors of C1r serine protease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.74 | 5.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10768 | — | — | 1 | 5.35 |
| CHEMBL10378 | — | — | 1 | 4.82 |
| CHEMBL10527 | — | — | 1 | 4.06 |
| CHEMBL10312 | — | — | 1 | - |
| CHEMBL10065 | — | — | 1 | - |
| CHEMBL274211 | — | — | 1 | - |
| CHEMBL274816 | — | — | 1 | - |
| CHEMBL274319 | — | — | 1 | - |
| CHEMBL10248 | — | — | 1 | - |
| CHEMBL10435 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10768 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL10378 | — | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL10527 | — | IC50 | = | 87100.0 | nM | 4.06 |
| CHEMBL10312 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL10065 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL274211 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL274816 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL274319 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL10248 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL10435 | — | IC50 | > | 100000.0 | nM | - |