Assay Detail
Binding
CHEMBL818375
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Binding affinity was evaluated by measuring the displacement of [3H]-AVP (arginine vasopressin) from specific binding sites in kidney medulla obtained from rats
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Kidney |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
1-(1-[4-[(N-acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]piperidin-4- yl)-4H-3,1-benzoxazin-2(1H)-one (L-371,257): a new, orally bioavailable, non-peptide oxytocin antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 4.79 | 4.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL344752 | — | — | 1 | 4.96 |
| CHEMBL142324 | — | — | 1 | 4.96 |
| CHEMBL358793 | — | — | 1 | 4.46 |
| CHEMBL24781 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL344752 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL142324 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL358793 | — | Ki | = | 35000.0 | nM | 4.46 |
| CHEMBL24781 | — | Ki | > | 30000.0 | nM | - |