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Assay Detail

CHEMBL818488

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Biotinylated fibrinogen binding to alpha IIb beta-3 integrin
16
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 6 — Multiple protein complex / RNA
Curated By Autocuration

Target

Integrin alpha-IIb/beta-3 (CHEMBL2093869)
Type PROTEIN COMPLEX
Organism Homo sapiens

Publication

Tetrahydrothienopyridine derivatives as novel GPIIb/IIIa antagonists
Katano K, Shitara E, Shimizu M, Sasaki K, Miura T, Isomura Y, Kawaguchi M, Ohuchi S, Tsuruoka T
Bioorg Med Chem Lett (1996) 6 : 2601 -2606
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 7.81 8.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL87462 1 8.85
CHEMBL315036 2 8.33
CHEMBL314519 1 8.22
CHEMBL423132 1 8.06
CHEMBL313434 1 8.01
CHEMBL89016 1 7.75
CHEMBL432058 1 7.51
CHEMBL89257 1 7.38
CHEMBL313469 1 7.21
CHEMBL89704 1 7.10
CHEMBL87104 1 7.00
CHEMBL89680 1 -
CHEMBL86671 1 -
CHEMBL89131 1 -
CHEMBL85131 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL87462 IC50 = 1.4 nM 8.85
CHEMBL315036 IC50 = 4.7 nM 8.33
CHEMBL315036 IC50 = 5.6 nM 8.25
CHEMBL314519 IC50 = 6.0 nM 8.22
CHEMBL423132 IC50 = 8.7 nM 8.06
CHEMBL313434 IC50 = 9.8 nM 8.01
CHEMBL89016 IC50 = 18.0 nM 7.75
CHEMBL432058 IC50 = 31.0 nM 7.51
CHEMBL89257 IC50 = 42.0 nM 7.38
CHEMBL313469 IC50 = 62.0 nM 7.21
CHEMBL89704 IC50 = 80.0 nM 7.10
CHEMBL87104 IC50 = 100.0 nM 7.00
CHEMBL89680 IC50 > 100.0 nM -
CHEMBL86671 IC50 > 100.0 nM -
CHEMBL89131 IC50 > 1000.0 nM -
CHEMBL85131 IC50 > 1000.0 nM -