Assay Detail
Binding
CHEMBL818676
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Inhibitory activity against Human cathepsin L
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Azepanone-based inhibitors of human and rat cathepsin K.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.65 | 9.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL284939 | — | — | 1 | 9.31 |
| CHEMBL286364 | — | — | 1 | 8.66 |
| CHEMBL281086 | — | — | 1 | 7.80 |
| CHEMBL29483 | — | — | 1 | 7.41 |
| CHEMBL31947 | — | — | 1 | 7.33 |
| CHEMBL286034 | — | — | 1 | 6.54 |
| CHEMBL281540 | — | — | 1 | 6.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL284939 | — | Ki | = | 0.49 | nM | 9.31 |
| CHEMBL286364 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL281086 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL29483 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL31947 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL286034 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL281540 | — | Ki | = | 340.0 | nM | 6.47 |