Assay Detail
Binding
CHEMBL818677
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Inhibitory activity against Human cathepsin S
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Azepanone-based inhibitors of human and rat cathepsin K.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.43 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL286364 | — | — | 1 | 8.40 |
| CHEMBL284939 | — | — | 1 | 7.85 |
| CHEMBL31545 | — | — | 1 | 7.70 |
| CHEMBL31947 | — | — | 1 | 7.58 |
| CHEMBL286034 | — | — | 1 | 7.01 |
| CHEMBL281540 | — | — | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL286364 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL284939 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL31545 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL31947 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL286034 | — | Ki | = | 97.0 | nM | 7.01 |
| CHEMBL281540 | — | Ki | = | 890.0 | nM | 6.05 |