Assay Detail
Functional
CHEMBL818740
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonistic activity against vanilloid receptor as concentration to reduce the response to 0.5 mM capsaicin by 50% from neonatal rat culture spinal sensory neurons using [Ca2+] -influx assay
23
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis of N,N',N"-trisubstituted thiourea derivatives and their antagonist effect on the vanilloid receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 8.72 | 9.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL415543 | — | — | 2 | 9.49 |
| CHEMBL155433 | — | — | 1 | 9.34 |
| CHEMBL154743 | — | — | 1 | 9.30 |
| CHEMBL156041 | — | — | 1 | 9.26 |
| CHEMBL267205 | — | — | 1 | 9.14 |
| CHEMBL155730 | — | — | 1 | 9.02 |
| CHEMBL154990 | — | — | 1 | 9.02 |
| CHEMBL157962 | — | — | 1 | 8.92 |
| CHEMBL422702 | — | — | 1 | 8.62 |
| CHEMBL434295 | — | — | 1 | 8.60 |
| CHEMBL156693 | — | — | 1 | 8.52 |
| CHEMBL356682 | — | — | 1 | 8.49 |
| CHEMBL157917 | — | — | 1 | 8.29 |
| CHEMBL158189 | — | — | 1 | 8.21 |
| CHEMBL156927 | — | — | 1 | 8.03 |
| CHEMBL345157 | — | — | 1 | 8.00 |
| CHEMBL157918 | — | — | 1 | 7.98 |
| CHEMBL157579 | — | — | 1 | 7.92 |
| CHEMBL157688 | — | — | 1 | - |
| CHEMBL348634 | — | — | 1 | - |
| CHEMBL391997 | CAPSAZEPINE | — | 1 | - |
| CHEMBL157473 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL415543 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL415543 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL155433 | — | IC50 | = | 0.46 | nM | 9.34 |
| CHEMBL154743 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL156041 | — | IC50 | = | 0.55 | nM | 9.26 |
| CHEMBL267205 | — | IC50 | = | 0.72 | nM | 9.14 |
| CHEMBL154990 | — | IC50 | = | 0.95 | nM | 9.02 |
| CHEMBL155730 | — | IC50 | = | 0.95 | nM | 9.02 |
| CHEMBL157962 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL422702 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL434295 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL156693 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL356682 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL157917 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL158189 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL156927 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL345157 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL157918 | — | IC50 | = | 10.5 | nM | 7.98 |
| CHEMBL157579 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL391997 | CAPSAZEPINE | IC50 | = | 650000.0 | nM | - |
| CHEMBL157688 | — | IC50 | > | 30.0 | nM | - |
| CHEMBL157473 | — | IC50 | > | 30.0 | nM | - |
| CHEMBL348634 | — | IC50 | > | 30.0 | nM | - |