Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL818810

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against arginine vasopressin V2 receptor using [3H]AVP as radioligand in rat adrenal medulla
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Tissue Adrenal medulla
Confidence 9 — Direct single protein target
Curated By Expert

Target

Vasopressin V2 receptor (CHEMBL3766)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

New analgesic drugs derived from phencyclidine.
Itzhak Y, Kalir A, Weissman BA, Cohen S.
J Med Chem (1981) 24 : 496 -499
PubMed 7241506 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 6.74 7.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL368791 1 7.70
CHEMBL175930 1 7.52
CHEMBL177556 1 7.30
CHEMBL369712 1 7.00
CHEMBL175211 1 6.70
CHEMBL441498 1 6.70
CHEMBL420762 MOZAVAPTAN 4.0 1 6.52
CHEMBL175411 1 6.52
CHEMBL175813 1 6.51
CHEMBL176264 1 6.42
CHEMBL360272 1 5.29
CHEMBL368462 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL368791 IC50 = 20.0 nM 7.70
CHEMBL175930 IC50 = 30.0 nM 7.52
CHEMBL177556 IC50 = 50.0 nM 7.30
CHEMBL369712 IC50 = 100.0 nM 7.00
CHEMBL175211 IC50 = 200.0 nM 6.70
CHEMBL441498 IC50 = 200.0 nM 6.70
CHEMBL420762 MOZAVAPTAN IC50 = 300.0 nM 6.52
CHEMBL175411 IC50 = 300.0 nM 6.52
CHEMBL175813 IC50 = 310.0 nM 6.51
CHEMBL176264 IC50 = 380.0 nM 6.42
CHEMBL360272 IC50 = 5100.0 nM 5.29
CHEMBL368462 IC50 < 10.0 nM -