Assay Detail
Binding
CHEMBL818902
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Inhibitory activity against avian c-Src tyrosine kinase was determined.
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Aves |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and structure-activity relationships of 7-substituted 3-(2, 6-dichlorophenyl)-1,6-naphthyridin-2(1H)-ones as selective inhibitors of pp60(c-src).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 47 | 6.96 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL106772 | — | — | 1 | 8.10 |
| CHEMBL49120 | PD-0166285 | 1.0 | 1 | 8.05 |
| CHEMBL51283 | — | — | 1 | 8.00 |
| CHEMBL104779 | — | — | 1 | 8.00 |
| CHEMBL419914 | — | — | 1 | 7.96 |
| CHEMBL104357 | — | — | 1 | 7.85 |
| CHEMBL110403 | — | — | 1 | 7.80 |
| CHEMBL104153 | — | — | 1 | 7.70 |
| CHEMBL301612 | — | — | 1 | 7.70 |
| CHEMBL104414 | — | — | 1 | 7.64 |
| CHEMBL107423 | — | — | 1 | 7.62 |
| CHEMBL104071 | — | — | 1 | 7.55 |
| CHEMBL107458 | — | — | 1 | 7.50 |
| CHEMBL108332 | — | — | 1 | 7.46 |
| CHEMBL108333 | — | — | 1 | 7.39 |
| CHEMBL104322 | — | — | 1 | 7.38 |
| CHEMBL107676 | — | — | 1 | 7.36 |
| CHEMBL320382 | — | — | 1 | 7.35 |
| CHEMBL108013 | — | — | 1 | 7.23 |
| CHEMBL106232 | — | — | 1 | 7.22 |
| CHEMBL104244 | — | — | 1 | 7.16 |
| CHEMBL107277 | — | — | 1 | 7.11 |
| CHEMBL104304 | — | — | 1 | 6.96 |
| CHEMBL299194 | — | — | 1 | 6.82 |
| CHEMBL106295 | — | — | 1 | 6.70 |
| CHEMBL106992 | — | — | 1 | 6.60 |
| CHEMBL49596 | — | — | 1 | 6.58 |
| CHEMBL420477 | — | — | 1 | 6.52 |
| CHEMBL108004 | — | — | 1 | 6.46 |
| CHEMBL107071 | — | — | 1 | 6.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL106772 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL49120 | PD-0166285 | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL104779 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL51283 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL419914 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL104357 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL110403 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL104153 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL301612 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL104414 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL107423 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL104071 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL107458 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL108332 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL108333 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL104322 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL107676 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL320382 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL108013 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL106232 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL104244 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL107277 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL104304 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL299194 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL106295 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL106992 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL49596 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL420477 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL108004 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL107071 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL48172 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL106953 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL106839 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL107472 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL323453 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL50470 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL322005 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL318519 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL107418 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL106379 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL108170 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL107177 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL420473 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL104532 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL107247 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL107372 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL323017 | — | IC50 | > | 50000.0 | nM | - |