Compound Detail
CHEMBL106379
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Basic Information
| ChEMBL ID | CHEMBL106379 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZKUIGFKRPUCRRC-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
511.4
MW (Da)
6.37
ALogP
6
HBA
1
HBD
59.4
PSA (Ų)
0.28
QED
2
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.54
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Proto-oncogene tyrosine-protein kinase Src CHEMBL267 | IC50 | 4.54 | 4.54 | 29000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Proto-oncogene tyrosine-protein kinase Src | IC50 | = | 29000.0 | nM | 4.54 | Inhibitory activity against avian c-Src tyrosine kinase was determined. | 10956222 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10956222 | 10.1021/jm000148t | Proto-oncogene tyrosine-protein kinase Src | 1 |
| 10956222 | 10.1021/jm000148t | Platelet-derived growth factor receptor beta | 1 |
| 10956222 | 10.1021/jm000148t | Fibroblast growth factor receptor 1 | 1 |
Data from ChEMBL 36 via Core Engine