Assay Detail
Binding
CHEMBL818975
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In vitro inhibition of purified bovine brain tubulin polymerisation in the absence of microtubule-associated proteins.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Tubulin binding of conformationally restricted bis-aryl compounds
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.24 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10557 | — | — | 1 | 5.85 |
| CHEMBL10121 | — | — | 1 | 5.82 |
| CHEMBL10215 | — | — | 1 | 5.62 |
| CHEMBL81233 | — | — | 1 | 5.62 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 5.60 |
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 5.60 |
| CHEMBL81845 | — | — | 1 | 5.30 |
| CHEMBL79591 | — | — | 1 | 5.28 |
| CHEMBL10127 | — | — | 1 | 5.24 |
| CHEMBL79720 | — | — | 1 | 5.12 |
| CHEMBL82023 | — | — | 1 | 4.92 |
| CHEMBL82024 | — | — | 1 | 4.17 |
| CHEMBL81794 | — | — | 1 | 4.01 |
| CHEMBL79497 | — | — | 1 | - |
| CHEMBL81010 | — | — | 1 | - |
| CHEMBL79985 | — | — | 1 | - |
| CHEMBL309538 | — | — | 1 | - |
| CHEMBL81280 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10557 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL10121 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL10215 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL81233 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL107 | COLCHICINE | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL61 | PODOFILOX | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL81845 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL79591 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL10127 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL79720 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL82023 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL82024 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL81794 | — | IC50 | = | 98000.0 | nM | 4.01 |
| CHEMBL79497 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL81010 | — | IC50 | > | 125000.0 | nM | - |
| CHEMBL79985 | — | IC50 | = | 104000.0 | nM | - |
| CHEMBL309538 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL81280 | — | IC50 | = | 150000.0 | nM | - |