Compound Detail
CHEMBL10215
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Basic Information
| ChEMBL ID | CHEMBL10215 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XIRGZCOAKDMFGK-UHFFFAOYSA-N |
3
Targets
5
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
332.4
MW (Da)
3.60
ALogP
5
HBA
1
HBD
57.1
PSA (Ų)
0.80
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 6.52
Target Activity Profile
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| HL-60 | IC50 | = | 300.0 | nM | 6.52 | Cytotoxicity of compound against HL-60 human leukemia cells | 1552500 |
| L1210 | IC50 | = | 400.0 | nM | 6.4 | Compound was tested for the inhibition of murine L1210 leukemia cells growth by ... | 1552500 |
| Tubulin | IC50 | = | 2400.0 | nM | 5.62 | In vitro inhibition of purified bovine brain tubulin polymerisation in the absen... | - |
| Tubulin | IC50 | = | 3000.0 | nM | 5.52 | Inhibition of glutamate-dependent tubulin polymerization at 30 degrees C(0.25 mM... | 1552500 |
| Tubulin | IC50 | = | 11000.0 | nM | 4.96 | Concentration required to inhibit the extent of glutamate-dependent tubulin poly... | 1552500 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 1552500 | 10.1021/jm00084a011 | Tubulin | 4 |
| - | 10.1016/S0960-894X(01)81034-9 | Tubulin | 1 |
| 1552500 | 10.1021/jm00084a011 | HL-60 | 1 |
| 1552500 | 10.1021/jm00084a011 | L1210 | 1 |
Data from ChEMBL 36 via Core Engine