Assay Detail
Functional
CHEMBL818980
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Concentration required to inhibit the extent of glutamate-dependent tubulin polymerization by 50% at 37 degrees C(1.0 mM MgCl2)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Bos taurus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis of alkoxy-substituted diaryl compounds and correlation of ring separation with inhibition of tubulin polymerization: differential enhancement of inhibitory effects under suboptimal polymerization reaction conditions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.30 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18981 | THIOCOLCHICINE | — | 1 | 5.85 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.60 |
| CHEMBL10519 | — | — | 1 | 5.58 |
| CHEMBL10557 | — | — | 1 | 5.46 |
| CHEMBL10121 | — | — | 1 | 5.11 |
| CHEMBL10215 | — | — | 1 | 4.96 |
| CHEMBL10127 | — | — | 1 | 4.52 |
| CHEMBL10255 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18981 | THIOCOLCHICINE | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL10519 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL10557 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL10121 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL10215 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL10127 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL10255 | — | IC50 | > | 40000.0 | nM | - |