Compound Detail
CHEMBL10519
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Basic Information
| ChEMBL ID | CHEMBL10519 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZTSJEXNLURJMGW-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
298.3
MW (Da)
2.36
ALogP
5
HBA
0
HBD
69.7
PSA (Ų)
0.79
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tubulin CHEMBL2094134 | IC50 | 5.92 | 5.75 | 1200.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tubulin | IC50 | = | 1200.0 | nM | 5.92 | Inhibition of glutamate-dependent tubulin polymerization at 30 degrees C(0.25 mM... | 1552500 |
| Tubulin | IC50 | = | 2600.0 | nM | 5.58 | Concentration required to inhibit the extent of glutamate-dependent tubulin poly... | 1552500 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 1552500 | 10.1021/jm00084a011 | Tubulin | 4 |
Data from ChEMBL 36 via Core Engine