Assay Detail
Functional
CHEMBL818979
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of glutamate-dependent tubulin polymerization at 30 degrees C(0.25 mM MgCl2)
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Bos taurus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis of alkoxy-substituted diaryl compounds and correlation of ring separation with inhibition of tubulin polymerization: differential enhancement of inhibitory effects under suboptimal polymerization reaction conditions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.58 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18981 | THIOCOLCHICINE | — | 1 | 6.19 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.96 |
| CHEMBL10519 | — | — | 1 | 5.92 |
| CHEMBL10557 | — | — | 1 | 5.80 |
| CHEMBL10144 | — | — | 1 | 5.75 |
| CHEMBL10642 | — | — | 1 | 5.72 |
| CHEMBL274212 | — | — | 1 | 5.70 |
| CHEMBL10121 | — | — | 1 | 5.64 |
| CHEMBL10703 | — | — | 1 | 5.60 |
| CHEMBL275976 | — | — | 1 | 5.57 |
| CHEMBL10215 | — | — | 1 | 5.52 |
| CHEMBL273261 | — | — | 1 | 5.42 |
| CHEMBL10686 | — | — | 1 | 5.42 |
| CHEMBL10559 | — | — | 1 | 5.41 |
| CHEMBL10127 | — | — | 1 | 5.36 |
| CHEMBL10405 | — | — | 1 | 5.27 |
| CHEMBL10185 | — | — | 1 | 5.12 |
| CHEMBL269215 | — | — | 1 | 5.06 |
| CHEMBL10255 | — | — | 1 | - |
| CHEMBL10653 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18981 | THIOCOLCHICINE | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL10519 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL10557 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL10144 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL10642 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL274212 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL10121 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL10703 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL275976 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL10215 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL273261 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL10686 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL10559 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL10127 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL10405 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL10185 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL269215 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL10255 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL10653 | — | IC50 | > | 40000.0 | nM | - |