Assay Detail
Functional
CHEMBL689194
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Cytotoxicity of compound against HL-60 human leukemia cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of alkoxy-substituted diaryl compounds and correlation of ring separation with inhibition of tubulin polymerization: differential enhancement of inhibitory effects under suboptimal polymerization reaction conditions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.94 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10557 | — | — | 1 | 7.30 |
| CHEMBL10121 | — | — | 1 | 7.00 |
| CHEMBL10215 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10557 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL10121 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL10215 | — | IC50 | = | 300.0 | nM | 6.52 |