Assay Detail
Functional
CHEMBL818977
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of polymerization of purified bovine tubulin
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Bos taurus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis of B-ring homologated estradiol analogues that modulate tubulin polymerization and microtubule stability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.17 | 6.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1627442 | — | — | 1 | 6.18 |
| CHEMBL78894 | — | — | 1 | 6.07 |
| CHEMBL78844 | — | — | 1 | 6.01 |
| CHEMBL299613 | 2-METHOXYESTRADIOL | 2.0 | 1 | 5.85 |
| CHEMBL1627880 | — | — | 1 | 5.52 |
| CHEMBL310910 | — | — | 1 | 5.26 |
| CHEMBL310453 | — | — | 1 | 5.16 |
| CHEMBL311173 | — | — | 1 | 5.09 |
| CHEMBL302676 | — | — | 1 | 4.52 |
| CHEMBL82187 | — | — | 1 | 4.24 |
| CHEMBL78389 | — | — | 1 | 4.10 |
| CHEMBL81116 | — | — | 1 | 4.00 |
| CHEMBL432546 | — | — | 1 | - |
| CHEMBL310615 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1627442 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL78894 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL78844 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL299613 | 2-METHOXYESTRADIOL | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1627880 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL310910 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL310453 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL311173 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL302676 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL82187 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL78389 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL81116 | — | IC50 | = | 99000.0 | nM | 4.00 |
| CHEMBL432546 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL310615 | — | IC50 | > | 400000.0 | nM | - |