Assay Detail
Functional
CHEMBL818992
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Inhibition of Tumor necrosis factor alpha release from LPS-induced THP-1 cells by ELISA
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Hybrid-designed inhibitors of p38 MAP kinase utilizing N-arylpyridazinones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.27 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325706 | — | — | 1 | 8.22 |
| CHEMBL334215 | — | — | 1 | 8.00 |
| CHEMBL325854 | — | — | 1 | 7.85 |
| CHEMBL118651 | — | — | 1 | 7.70 |
| CHEMBL118466 | — | — | 1 | 7.66 |
| CHEMBL118187 | — | — | 1 | 7.17 |
| CHEMBL117109 | — | — | 1 | 7.16 |
| CHEMBL334184 | — | — | 1 | 6.79 |
| CHEMBL118768 | — | — | 1 | 6.79 |
| CHEMBL332391 | — | — | 1 | 6.77 |
| CHEMBL434409 | — | — | 1 | 6.75 |
| CHEMBL118917 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325706 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL334215 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL325854 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL118651 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL118466 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL118187 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL117109 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL334184 | — | IC50 | = | 161.0 | nM | 6.79 |
| CHEMBL118768 | — | IC50 | = | 161.0 | nM | 6.79 |
| CHEMBL332391 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL434409 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL118917 | — | IC50 | = | 400.0 | nM | 6.40 |