Assay Detail
Binding
CHEMBL819080
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against human thrombin
28
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and biological evaluation of potent and selective amidino bicyclic factor Xa inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 5.71 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL341920 | — | — | 1 | 6.70 |
| CHEMBL336661 | — | — | 1 | 6.70 |
| CHEMBL343380 | — | — | 1 | 6.40 |
| CHEMBL136986 | — | — | 1 | 6.30 |
| CHEMBL342168 | — | — | 1 | 6.10 |
| CHEMBL138956 | — | — | 1 | 6.05 |
| CHEMBL136846 | — | — | 2 | 6.05 |
| CHEMBL137499 | — | — | 1 | 6.00 |
| CHEMBL343784 | — | — | 1 | 5.92 |
| CHEMBL341979 | — | — | 2 | 5.82 |
| CHEMBL139432 | — | — | 1 | 5.77 |
| CHEMBL337785 | — | — | 1 | 5.72 |
| CHEMBL140016 | — | — | 1 | 5.70 |
| CHEMBL138709 | — | — | 1 | 5.68 |
| CHEMBL136215 | — | — | 1 | 5.68 |
| CHEMBL343495 | — | — | 1 | 5.66 |
| CHEMBL335340 | — | — | 1 | 5.57 |
| CHEMBL139970 | — | — | 1 | 5.55 |
| CHEMBL343827 | — | — | 1 | 5.33 |
| CHEMBL136100 | — | — | 1 | 5.17 |
| CHEMBL141259 | — | — | 1 | 4.90 |
| CHEMBL138478 | — | — | 1 | 4.85 |
| CHEMBL342036 | — | — | 1 | 4.68 |
| CHEMBL136297 | — | — | 1 | - |
| CHEMBL136591 | — | — | 1 | - |
| CHEMBL139682 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL341920 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL336661 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL343380 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL136986 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL342168 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL138956 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL136846 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL137499 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL343784 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL341979 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL136846 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL139432 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL337785 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL140016 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL136215 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL138709 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL343495 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL335340 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL139970 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL343827 | — | Ki | = | 4700.0 | nM | 5.33 |
| CHEMBL136100 | — | Ki | = | 6800.0 | nM | 5.17 |
| CHEMBL141259 | — | Ki | = | 12500.0 | nM | 4.90 |
| CHEMBL138478 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL341979 | — | Ki | = | 17000.0 | nM | 4.77 |
| CHEMBL342036 | — | Ki | = | 21000.0 | nM | 4.68 |
| CHEMBL139682 | — | Ki | > | 21000.0 | nM | - |
| CHEMBL136591 | — | Ki | > | 21000.0 | nM | - |
| CHEMBL136297 | — | Ki | > | 21000.0 | nM | - |