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Assay Detail

CHEMBL819189

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of alpha-chymotrypsin
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Chymotrypsinogen A (CHEMBL3314)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Alpha-diketone and alpha-keto ester derivatives of N-protected amino acids and peptides as novel inhibitors of cysteine and serine proteinases.
Angelastro MR, Mehdi S, Burkhart JP, Peet NP, Bey P.
J Med Chem (1990) 33 : 11 -13
PubMed 2296008 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 13 5.83 7.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL25945 1 7.22
CHEMBL282374 1 7.22
CHEMBL277191 1 6.89
CHEMBL26066 1 6.82
CHEMBL24283 1 6.70
CHEMBL26283 1 5.92
CHEMBL24309 1 5.64
CHEMBL26056 1 5.62
CHEMBL287319 1 5.11
CHEMBL24108 1 4.35
CHEMBL286722 1 4.27
CHEMBL287136 1 4.19
CHEMBL412423 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL25945 Ki = 60.0 nM 7.22
CHEMBL282374 Ki = 60.0 nM 7.22
CHEMBL277191 Ki = 130.0 nM 6.89
CHEMBL26066 Ki = 150.0 nM 6.82
CHEMBL24283 Ki = 200.0 nM 6.70
CHEMBL26283 Ki = 1200.0 nM 5.92
CHEMBL24309 Ki = 2300.0 nM 5.64
CHEMBL26056 Ki = 2400.0 nM 5.62
CHEMBL287319 Ki = 7700.0 nM 5.11
CHEMBL24108 Ki = 45000.0 nM 4.35
CHEMBL286722 Ki = 54000.0 nM 4.27
CHEMBL287136 Ki = 64000.0 nM 4.19
CHEMBL412423 Ki = 360000.0 nM -