Assay Detail
Functional
CHEMBL819219
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In vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscle
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Soleus muscle |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino] propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent beta-adrenergic agonist virtually specific for beta 3 receptors. A promising antidiabetic and antiobesity agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.46 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434 | ISOPROTERENOL | 4.0 | 1 | 8.28 |
| CHEMBL284782 | — | — | 1 | 6.72 |
| CHEMBL38486 | — | — | 1 | 6.30 |
| CHEMBL32590 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434 | ISOPROTERENOL | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL284782 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL38486 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL32590 | — | IC50 | = | 30000.0 | nM | 4.52 |