Assay Detail
Binding
CHEMBL819248
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration that cause a 50% inhibition in tubulin assembly as measured by an increase in turbidity using microtubule assembly assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
The total synthesis of an aurone isolated from Uvaria hamiltonii: aurones and flavones as anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.19 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9859 | — | — | 1 | 6.30 |
| CHEMBL126094 | — | — | 1 | 4.66 |
| CHEMBL123092 | — | — | 1 | 4.60 |
| CHEMBL124392 | — | — | 1 | - |
| CHEMBL122974 | — | — | 1 | - |
| CHEMBL125287 | — | — | 1 | - |
| CHEMBL124885 | — | — | 1 | - |
| CHEMBL339935 | — | — | 1 | - |
| CHEMBL122075 | — | — | 1 | - |
| CHEMBL125757 | — | — | 1 | - |
| CHEMBL123786 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9859 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL126094 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL123092 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL124392 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL122974 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL125287 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL124885 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL339935 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL122075 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL125757 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL123786 | — | IC50 | > | 50000.0 | nM | - |