Assay Detail
Binding
CHEMBL819249
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of mammalian tubulin polymerization by 50%
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Antitumor agents. 185. Synthesis and biological evaluation of tridemethylthiocolchicine analogues as novel topoisomerase II inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 5.70 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18981 | THIOCOLCHICINE | — | 1 | 6.19 |
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 6.00 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 5.82 |
| CHEMBL277239 | — | — | 1 | 5.70 |
| CHEMBL277998 | — | — | 1 | 5.70 |
| CHEMBL301851 | — | — | 1 | 5.40 |
| CHEMBL61573 | — | — | 1 | 5.40 |
| CHEMBL291722 | — | — | 1 | 5.40 |
| CHEMBL293815 | — | — | 1 | - |
| CHEMBL294164 | — | — | 1 | - |
| CHEMBL553116 | — | — | 1 | - |
| CHEMBL293561 | — | — | 1 | - |
| CHEMBL558424 | — | — | 1 | - |
| CHEMBL61609 | — | — | 1 | - |
| CHEMBL292980 | — | — | 1 | - |
| CHEMBL58428 | — | — | 1 | - |
| CHEMBL445096 | — | — | 1 | - |
| CHEMBL300544 | — | — | 1 | - |
| CHEMBL433835 | — | — | 1 | - |
| CHEMBL58069 | — | — | 1 | - |
| CHEMBL300164 | — | — | 1 | - |
| CHEMBL59083 | — | — | 1 | - |
| CHEMBL61707 | — | — | 1 | - |
| CHEMBL58503 | — | — | 1 | - |
| CHEMBL292398 | — | — | 1 | - |
| CHEMBL294836 | — | — | 1 | - |
| CHEMBL61082 | — | — | 1 | - |
| CHEMBL58440 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18981 | THIOCOLCHICINE | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL61 | PODOFILOX | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL107 | COLCHICINE | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL277239 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL277998 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL301851 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL61573 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL291722 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL293815 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL294164 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL553116 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL293561 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL558424 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL61609 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL292980 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL58428 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL445096 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL300544 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL433835 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL58069 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL300164 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL59083 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL61707 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL58503 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL292398 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL294836 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL61082 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL58440 | — | IC50 | > | 40000.0 | nM | - |