Assay Detail
Functional
CHEMBL819251
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Inhibition of Tubulin polymerization after 20 minutes of administration at 30 degree Centigrade
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Antitumor agents. 172. Synthesis and biological evaluation of novel deacetamidothiocolchicin-7-ols and ester analogs as antitubulin agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.89 | 6.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49847 | — | — | 1 | 6.25 |
| CHEMBL368670 | — | — | 1 | 6.22 |
| CHEMBL18981 | THIOCOLCHICINE | — | 1 | 6.19 |
| CHEMBL49518 | — | — | 1 | 6.12 |
| CHEMBL368737 | THIOCOLCHICONE | — | 1 | 6.12 |
| CHEMBL176684 | — | — | 1 | 6.12 |
| CHEMBL173603 | — | — | 1 | 6.07 |
| CHEMBL173025 | — | — | 1 | 6.06 |
| CHEMBL555514 | — | — | 1 | 6.01 |
| CHEMBL177199 | — | — | 1 | 5.96 |
| CHEMBL173511 | — | — | 1 | 5.96 |
| CHEMBL172557 | — | — | 1 | 5.92 |
| CHEMBL355794 | — | — | 1 | 5.89 |
| CHEMBL298240 | — | — | 1 | 5.89 |
| CHEMBL291449 | — | — | 1 | 5.85 |
| CHEMBL176317 | — | — | 1 | 5.85 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 5.82 |
| CHEMBL176535 | — | — | 1 | 5.82 |
| CHEMBL368320 | — | — | 1 | 5.58 |
| CHEMBL427472 | — | — | 1 | 5.21 |
| CHEMBL368071 | — | — | 1 | 4.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49847 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL368670 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL18981 | THIOCOLCHICINE | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL49518 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL368737 | THIOCOLCHICONE | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL176684 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL173603 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL173025 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL555514 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL177199 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL173511 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL172557 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL355794 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL298240 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL291449 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL176317 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL107 | COLCHICINE | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL176535 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL368320 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL427472 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL368071 | — | IC50 | = | 17000.0 | nM | 4.77 |