Assay Detail
Functional
CHEMBL819428
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonistic activity towards beta-2 adrenoceptor. Mean concentration required to produce 50% inhibition of uterine contraction
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of novel N-phenylglycine derivatives as potent and selective beta(3)-adrenoceptor agonists for the treatment of frequent urination and urinary incontinence.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.05 | 8.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL284782 | — | — | 1 | 8.04 |
| CHEMBL83063 | RITODRINE | 4.0 | 1 | 7.62 |
| CHEMBL32933 | — | — | 1 | 7.21 |
| CHEMBL32470 | — | — | 1 | 6.60 |
| CHEMBL289670 | — | — | 1 | 6.55 |
| CHEMBL32532 | — | — | 1 | 6.19 |
| CHEMBL284520 | — | — | 1 | 5.89 |
| CHEMBL32586 | — | — | 1 | 5.85 |
| CHEMBL32939 | — | — | 1 | 5.85 |
| CHEMBL33360 | — | — | 1 | 5.80 |
| CHEMBL285888 | — | — | 1 | 5.77 |
| CHEMBL35738 | — | — | 1 | 5.66 |
| CHEMBL33399 | — | — | 1 | 5.59 |
| CHEMBL32670 | — | — | 1 | 5.48 |
| CHEMBL32590 | — | — | 1 | 5.01 |
| CHEMBL35459 | — | — | 1 | 4.96 |
| CHEMBL32391 | — | — | 1 | 4.85 |
| CHEMBL32115 | — | — | 1 | - |
| CHEMBL417137 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL284782 | — | IC50 | = | 9.12 | nM | 8.04 |
| CHEMBL83063 | RITODRINE | IC50 | = | 23.99 | nM | 7.62 |
| CHEMBL32933 | — | IC50 | = | 61.66 | nM | 7.21 |
| CHEMBL32470 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL289670 | — | IC50 | = | 281.84 | nM | 6.55 |
| CHEMBL32532 | — | IC50 | = | 645.65 | nM | 6.19 |
| CHEMBL284520 | — | IC50 | = | 1288.25 | nM | 5.89 |
| CHEMBL32586 | — | IC50 | = | 1412.54 | nM | 5.85 |
| CHEMBL32939 | — | IC50 | = | 1412.54 | nM | 5.85 |
| CHEMBL33360 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL285888 | — | IC50 | = | 1698.24 | nM | 5.77 |
| CHEMBL35738 | — | IC50 | = | 2187.76 | nM | 5.66 |
| CHEMBL33399 | — | IC50 | = | 2570.4 | nM | 5.59 |
| CHEMBL32670 | — | IC50 | = | 3311.31 | nM | 5.48 |
| CHEMBL32590 | — | IC50 | = | 9772.37 | nM | 5.01 |
| CHEMBL35459 | — | IC50 | = | 10964.78 | nM | 4.96 |
| CHEMBL32391 | — | IC50 | = | 14125.38 | nM | 4.85 |
| CHEMBL32115 | — | IC50 | < | 100000.0 | nM | - |
| CHEMBL417137 | — | IC50 | < | 100000.0 | nM | - |