Assay Detail
Functional
CHEMBL819430
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Agonistic activity towards beta-3 adrenoceptor. Mean concentration required to produce 50% relaxation of detrusor before the addition in the ferret detrusor
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Discovery of novel N-phenylglycine derivatives as potent and selective beta(3)-adrenoceptor agonists for the treatment of frequent urination and urinary incontinence.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 7.39 | 9.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL32670 | — | — | 1 | 9.03 |
| CHEMBL284782 | — | — | 1 | 8.66 |
| CHEMBL32586 | — | — | 1 | 8.25 |
| CHEMBL32933 | — | — | 1 | 8.14 |
| CHEMBL32115 | — | — | 1 | 7.96 |
| CHEMBL32470 | — | — | 1 | 7.89 |
| CHEMBL32391 | — | — | 1 | 7.85 |
| CHEMBL35459 | — | — | 1 | 7.64 |
| CHEMBL32532 | — | — | 1 | 7.62 |
| CHEMBL32590 | — | — | 1 | 7.60 |
| CHEMBL33360 | — | — | 1 | 7.28 |
| CHEMBL284520 | — | — | 1 | 7.21 |
| CHEMBL33399 | — | — | 1 | 7.09 |
| CHEMBL417137 | — | — | 1 | 6.80 |
| CHEMBL83063 | RITODRINE | 4.0 | 1 | 6.72 |
| CHEMBL285888 | — | — | 1 | 6.34 |
| CHEMBL32939 | — | — | 1 | 6.24 |
| CHEMBL35738 | — | — | 1 | 6.09 |
| CHEMBL289670 | — | — | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL32670 | — | EC50 | = | 0.9333 | nM | 9.03 |
| CHEMBL284782 | — | EC50 | = | 2.188 | nM | 8.66 |
| CHEMBL32586 | — | EC50 | = | 5.623 | nM | 8.25 |
| CHEMBL32933 | — | EC50 | = | 7.244 | nM | 8.14 |
| CHEMBL32115 | — | EC50 | = | 10.96 | nM | 7.96 |
| CHEMBL32470 | — | EC50 | = | 12.88 | nM | 7.89 |
| CHEMBL32391 | — | EC50 | = | 14.13 | nM | 7.85 |
| CHEMBL35459 | — | EC50 | = | 22.91 | nM | 7.64 |
| CHEMBL32532 | — | EC50 | = | 23.99 | nM | 7.62 |
| CHEMBL32590 | — | EC50 | = | 25.12 | nM | 7.60 |
| CHEMBL33360 | — | EC50 | = | 52.48 | nM | 7.28 |
| CHEMBL284520 | — | EC50 | = | 61.66 | nM | 7.21 |
| CHEMBL33399 | — | EC50 | = | 81.28 | nM | 7.09 |
| CHEMBL417137 | — | EC50 | = | 158.49 | nM | 6.80 |
| CHEMBL83063 | RITODRINE | EC50 | = | 190.55 | nM | 6.72 |
| CHEMBL285888 | — | EC50 | = | 457.09 | nM | 6.34 |
| CHEMBL32939 | — | EC50 | = | 575.44 | nM | 6.24 |
| CHEMBL35738 | — | EC50 | = | 812.83 | nM | 6.09 |
| CHEMBL289670 | — | EC50 | = | 831.76 | nM | 6.08 |