Assay Detail
Functional
CHEMBL819540
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Inhibitory activity against V79 (chinese hamster fibroblast) cell line without Escherichia coli nitroreductase combination after 72 hours drug exposure
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cricetulus griseus |
| Cell Type | V79 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Nitroaryl phosphoramides as novel prodrugs for E. coli nitroreductase activation in enzyme prodrug therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.17 | 4.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL144896 | — | — | 1 | 4.17 |
| CHEMBL142479 | — | — | 1 | - |
| CHEMBL143069 | — | — | 1 | - |
| CHEMBL142795 | — | — | 1 | - |
| CHEMBL23330 | TRETAZICAR | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL144896 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL142479 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL143069 | — | IC50 | = | 608000.0 | nM | - |
| CHEMBL142795 | — | IC50 | = | 832000.0 | nM | - |
| CHEMBL23330 | TRETAZICAR | IC50 | = | 254000.0 | nM | - |