Assay Detail

CHEMBL819739

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Binding

Kd for TEM-1 beta-lactamase

ChEMBL ↗

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Target

Beta-lactamase (CHEMBL2725) ↗

Open DB target context

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Beta-lactamase (CHEMBL2725) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Beta-lactamase

CHEMBL2725

Anchored from Assay target.

Protein identity Beta-lactamase

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	8 — Homologous single protein target
Curated By	Autocuration

Target

Beta-lactamase (CHEMBL2725) ↗

Type	SINGLE PROTEIN
Organism	Enterobacter cloacae

Publication

Mechanistic support for the stepwise process for inactivation of class A -lactamases by clavulanate

Miyashita K, Mobashery S
Bioorg Med Chem Lett (1995) 5 : 1043 -1048
· DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Kd	1	6.40	6.40

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL9306	LITHIUM CLAVULANATE	—	1	6.40

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL9306	LITHIUM CLAVULANATE	Kd	=	400.0	nM	6.40