Assay Detail
Functional
CHEMBL819802
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro vascular relaxation in canine coronary arteries precontracted with prostaglandin F2alpha.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Canis lupus familiaris |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Novel compounds possessing potent cAMP and cGMP phosphodiesterase inhibitory activity. Synthesis and cardiovascular effects of a series of imidazo[1,2-a]quinoxalinones and imidazo[1,5-a]quinoxalinones and their aza analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 21 | 5.36 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL730 | NITROGLYCERIN | 4.0 | 1 | 8.00 |
| CHEMBL92216 | — | — | 1 | 6.52 |
| CHEMBL330540 | — | — | 1 | 6.30 |
| CHEMBL420615 | — | — | 1 | 6.16 |
| CHEMBL189 | MILRINONE | 4.0 | 1 | 5.80 |
| CHEMBL92555 | — | — | 1 | 5.77 |
| CHEMBL91789 | — | — | 1 | 5.77 |
| CHEMBL88818 | — | — | 1 | 5.29 |
| CHEMBL90068 | — | — | 1 | 5.28 |
| CHEMBL90929 | — | — | 1 | 5.28 |
| CHEMBL92009 | — | — | 1 | 5.26 |
| CHEMBL275084 | ISOBUTYLMETHYLXANTHINE | — | 1 | 5.26 |
| CHEMBL316356 | — | — | 1 | 4.96 |
| CHEMBL312971 | — | — | 1 | 4.96 |
| CHEMBL327854 | — | — | 1 | 4.92 |
| CHEMBL88763 | — | — | 1 | 4.85 |
| CHEMBL90932 | — | — | 1 | 4.62 |
| CHEMBL88794 | — | — | 1 | 4.55 |
| CHEMBL90931 | — | — | 1 | 4.52 |
| CHEMBL443233 | — | — | 1 | 4.31 |
| CHEMBL93452 | — | — | 1 | 4.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL730 | NITROGLYCERIN | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL92216 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL330540 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL420615 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL189 | MILRINONE | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL92555 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL91789 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL88818 | — | EC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL90068 | — | EC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL90929 | — | EC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL92009 | — | EC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL275084 | ISOBUTYLMETHYLXANTHINE | EC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL316356 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL312971 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL327854 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL88763 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL90932 | — | EC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL88794 | — | EC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL90931 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL443233 | — | EC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL93452 | — | EC50 | = | 59000.0 | nM | 4.23 |