Assay Detail
Binding
CHEMBL819859
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to cause 50% decrease in the binding of [3H]colchicine from purified porcine tubulin.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Expert |
Publication
Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.76 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL150582 | — | — | 1 | 5.40 |
| CHEMBL356370 | — | — | 1 | 4.44 |
| CHEMBL345556 | — | — | 1 | 4.44 |
| CHEMBL150463 | — | — | 1 | - |
| CHEMBL150438 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL150582 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL356370 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL345556 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL150463 | — | IC50 | = | 298000.0 | nM | - |
| CHEMBL150438 | — | IC50 | = | 226000.0 | nM | - |