Assay Detail
Binding
CHEMBL819924
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Inhibition of NGF high affinity receptor tyrosine kinase TrkA
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
High affinity nerve growth factor receptor (CHEMBL2815) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Mixed lineage kinase activity of indolocarbazole analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.82 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL288229 | — | — | 1 | 7.21 |
| CHEMBL277817 | — | — | 1 | 6.68 |
| CHEMBL288817 | — | — | 1 | 6.57 |
| CHEMBL37529 | — | — | 1 | - |
| CHEMBL288818 | — | — | 1 | - |
| CHEMBL36891 | — | — | 1 | - |
| CHEMBL29709 | — | — | 1 | - |
| CHEMBL290352 | CEP-1347 | 3.0 | 1 | - |
| CHEMBL288816 | — | — | 1 | - |
| CHEMBL38338 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL288229 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL277817 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL288817 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL37529 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL288818 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL36891 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL29709 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL290352 | CEP-1347 | IC50 | > | 10000.0 | nM | - |
| CHEMBL288816 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL38338 | — | IC50 | > | 1000.0 | nM | - |