Assay Detail
Functional
CHEMBL820023
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Ability to inhibit mGluR1-alpha-mediated PI (phospho inositol) hydrolysis was determined at BHK cells at 100 Micro M Concentration
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mesocricetus auratus |
| Cell Type | BHK |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
1-Aminoindan-1,5-dicarboxylic acid: a novel antagonist at phospholipase C-linked metabotropic glutamate receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.58 | 5.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL313938 | — | — | 1 | 5.16 |
| CHEMBL444589 | — | — | 1 | 4.40 |
| CHEMBL328984 | — | — | 1 | 4.19 |
| CHEMBL299683 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL313938 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL444589 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL328984 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL299683 | — | IC50 | = | 155000.0 | nM | - |