Compound Detail
CHEMBL328984
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Basic Information
| ChEMBL ID | CHEMBL328984 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VTMJKPGFERYGJF-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
195.2
MW (Da)
0.47
ALogP
3
HBA
3
HBD
100.6
PSA (Ų)
0.65
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.19
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 1 CHEMBL3772 | IC50 | 4.19 | 4.19 | 65000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 1 | IC50 | = | 65000.0 | nM | 4.19 | Ability to inhibit mGluR1-alpha-mediated PI (phospho inositol) hydrolysis was de... | 7562903 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 7562903 | 10.1021/jm00019a002 | Metabotropic glutamate receptor 1 | 1 |
| 7562903 | 10.1021/jm00019a002 | Metabotropic glutamate receptor 2 | 1 |
| 7562903 | 10.1021/jm00019a002 | Metabotropic glutamate receptor 4 | 1 |
Data from ChEMBL 36 via Core Engine