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Assay Detail

CHEMBL820116

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity towards fMLF receptor using human neutrophils
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

fMet-Leu-Phe receptor (CHEMBL3359)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

N-terminus urea-substituted chemotactic peptides: new potent agonists and antagonists toward the neutrophil fMLF receptor.
Higgins JD, Bridger GJ, Derian CK, Beblavy MJ, Hernandez PE, Gaul FE, Abrams MJ, Pike MC, Solomon HF.
J Med Chem (1996) 39 : 1013 -1015
PubMed 8676333 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 6.72 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL267388 1 8.70
CHEMBL7753 1 8.70
CHEMBL266802 1 8.70
CHEMBL267179 N-FORMYLMETHIONYL-LEUCYLPHENYLALANINE 1 7.70
CHEMBL415296 1 7.70
CHEMBL7520 1 7.52
CHEMBL162488 1 7.30
CHEMBL6997 1 7.00
CHEMBL7122 1 6.70
CHEMBL7486 1 6.70
CHEMBL266089 1 6.52
CHEMBL7363 1 6.52
CHEMBL265408 1 6.52
CHEMBL6450 1 6.10
CHEMBL7226 1 6.10
CHEMBL6779 1 6.05
CHEMBL7214 1 6.00
CHEMBL268823 1 6.00
CHEMBL7306 1 5.70
CHEMBL7034 1 5.70
CHEMBL266448 1 5.70
CHEMBL7181 1 5.52
CHEMBL415299 1 5.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL267388 IC50 = 2.0 nM 8.70
CHEMBL7753 IC50 = 2.0 nM 8.70
CHEMBL266802 IC50 = 2.0 nM 8.70
CHEMBL267179 N-FORMYLMETHIONYL-LEUCYLPHENYLALANINE IC50 = 20.0 nM 7.70
CHEMBL415296 IC50 = 20.0 nM 7.70
CHEMBL7520 IC50 = 30.0 nM 7.52
CHEMBL162488 IC50 = 50.0 nM 7.30
CHEMBL6997 IC50 = 100.0 nM 7.00
CHEMBL7122 IC50 = 200.0 nM 6.70
CHEMBL7486 IC50 = 200.0 nM 6.70
CHEMBL266089 IC50 = 300.0 nM 6.52
CHEMBL7363 IC50 = 300.0 nM 6.52
CHEMBL265408 IC50 = 300.0 nM 6.52
CHEMBL6450 IC50 = 800.0 nM 6.10
CHEMBL7226 IC50 = 800.0 nM 6.10
CHEMBL6779 IC50 = 900.0 nM 6.05
CHEMBL7214 IC50 = 1000.0 nM 6.00
CHEMBL268823 IC50 = 1000.0 nM 6.00
CHEMBL7306 IC50 = 2000.0 nM 5.70
CHEMBL7034 IC50 = 2000.0 nM 5.70
CHEMBL266448 IC50 = 2000.0 nM 5.70
CHEMBL7181 IC50 = 3000.0 nM 5.52
CHEMBL415299 IC50 = 3000.0 nM 5.52