Assay Detail
Binding
CHEMBL820248
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to rat V2 receptor
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
The synthesis and vasopressin (AVP) antagonist activity of a novel series of N-aroyl-2,4,5,6-tetrahydropyrazolo[3,4-d]thieno[3,2-b]azepines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.14 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL347020 | — | — | 1 | 8.92 |
| CHEMBL159359 | — | — | 1 | 8.82 |
| CHEMBL49429 | LIXIVAPTAN | 3.0 | 1 | 8.64 |
| CHEMBL159823 | — | — | 1 | 8.59 |
| CHEMBL418890 | — | — | 1 | 8.51 |
| CHEMBL159856 | — | — | 1 | 8.49 |
| CHEMBL159831 | — | — | 1 | 7.72 |
| CHEMBL351587 | — | — | 1 | 7.62 |
| CHEMBL349506 | — | — | 1 | 7.42 |
| CHEMBL160029 | — | — | 1 | 6.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL347020 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL159359 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL49429 | LIXIVAPTAN | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL159823 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL418890 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL159856 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL159831 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL351587 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL349506 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL160029 | — | IC50 | = | 230.0 | nM | 6.64 |