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Assay Detail

CHEMBL820249

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Compound was tested for its antiviral activity against HSV-1(KOS strain) in vero cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Chlorocebus sabaeus
Cell Type Vero
Confidence 1 — Organism
Curated By Intermediate

Target

Vero (CHEMBL391)
Type CELL-LINE
Organism Chlorocebus sabaeus

Publication

Synthesis and evaluation of amino acid ester prodrugs of penciclovir
Kim D, Lee N, Im GJ, Kim Y, Chang K, Kim H, Cho Y, Choi W, Jung I, Kim KH
Bioorg Med Chem Lett (1996) 6 : 1849 -1854
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 12 4.61 5.09

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1540 PENCICLOVIR 4.0 1 5.09
CHEMBL553812 1 4.62
CHEMBL544031 1 4.59
CHEMBL541809 1 4.38
CHEMBL542621 1 4.37
CHEMBL545434 1 -
CHEMBL544503 1 -
CHEMBL880 FAMCICLOVIR 4.0 1 -
CHEMBL552623 1 -
CHEMBL542373 1 -
CHEMBL554434 1 -
CHEMBL544739 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1540 PENCICLOVIR EC50 = 8100.0 nM 5.09
CHEMBL553812 EC50 = 24200.0 nM 4.62
CHEMBL544031 EC50 = 25500.0 nM 4.59
CHEMBL541809 EC50 = 42000.0 nM 4.38
CHEMBL542621 EC50 = 42300.0 nM 4.37
CHEMBL545434 EC50 > 100000.0 nM -
CHEMBL544503 EC50 > 100000.0 nM -
CHEMBL880 FAMCICLOVIR EC50 > 100000.0 nM -
CHEMBL552623 EC50 > 100000.0 nM -
CHEMBL542373 EC50 > 100000.0 nM -
CHEMBL554434 EC50 > 100000.0 nM -
CHEMBL544739 EC50 > 100000.0 nM -