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Assay Detail

CHEMBL820316

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
in vitro cell based assay for measuring the IC50 values of osteoblast resorption.
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Cathepsin K (CHEMBL268)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Azepanone-based inhibitors of human and rat cathepsin K.
Marquis RW, Ru Y, LoCastro SM, Zeng J, Yamashita DS, Oh HJ, Erhard KF, Davis LD, Tomaszek TA, Tew D, Salyers K, Proksch J, Ward K, Smith B, Levy M, Cummings MD, Haltiwanger RC, Trescher G, Wang B, Hemling ME, Quinn CJ, Cheng HY, Lin F, Smith WW, Janson CA, Zhao B, McQueney MS, D'Alessio K, Lee CP, Marzulli A, Dodds RA, Blake S, Hwang SM, James IE, Gress CJ, Bradley BR, Lark MW, Gowen M, Veber DF.
J Med Chem (2001) 44 : 1380 -1395
PubMed 11311061 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 7.16 7.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL286364 1 7.16

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL286364 IC50 = 70.0 nM 7.16