Assay Detail
Binding
CHEMBL820317
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Inhibition of Human cathepsin K
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Azepanone-based inhibitors of human and rat cathepsin K.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 7.96 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL286364 | — | — | 1 | 9.80 |
| CHEMBL31381 | — | — | 1 | 8.80 |
| CHEMBL31947 | — | — | 1 | 8.70 |
| CHEMBL29483 | — | — | 1 | 8.64 |
| CHEMBL281086 | — | — | 1 | 8.59 |
| CHEMBL31218 | — | — | 1 | 8.33 |
| CHEMBL31545 | — | — | 1 | 8.12 |
| CHEMBL286034 | — | — | 1 | 7.82 |
| CHEMBL281540 | — | — | 1 | 7.66 |
| CHEMBL31519 | — | — | 1 | 7.52 |
| CHEMBL418213 | — | — | 1 | 7.27 |
| CHEMBL416579 | — | — | 1 | 6.17 |
| CHEMBL31674 | — | — | 1 | 6.01 |
| CHEMBL287705 | — | — | 1 | - |
| CHEMBL284939 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL286364 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL31381 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL31947 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL29483 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL281086 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL31218 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL31545 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL286034 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL281540 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL31519 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL418213 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL416579 | — | Ki | = | 670.0 | nM | 6.17 |
| CHEMBL31674 | — | Ki | = | 980.0 | nM | 6.01 |
| CHEMBL287705 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL284939 | — | Ki | = | 0.0048 | nM | - |