Assay Detail
Functional
CHEMBL820325
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro cytotoxicity against hypoxic V79-379A cells determined by MTT assay in the presence of air
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cricetulus griseus |
| Cell Type | V79-379A |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Indolequinone antitumor agents: reductive activation and elimination from (5-methoxy-1-methyl-4,7-dioxoindol-3-yl)methyl derivatives and hypoxia-selective cytotoxicity in vitro.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.17 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL329024 | — | — | 1 | 6.30 |
| CHEMBL328916 | — | — | 1 | 6.16 |
| CHEMBL94033 | — | — | 1 | 6.16 |
| CHEMBL328535 | — | — | 1 | 5.85 |
| CHEMBL307180 | — | — | 1 | 5.52 |
| CHEMBL93056 | — | — | 1 | 5.43 |
| CHEMBL94277 | — | — | 1 | 4.92 |
| CHEMBL93799 | — | — | 1 | 4.85 |
| CHEMBL329214 | — | — | 1 | 4.80 |
| CHEMBL329249 | — | — | 1 | 4.60 |
| CHEMBL94076 | — | — | 1 | 4.57 |
| CHEMBL93617 | — | — | 1 | 4.57 |
| CHEMBL330583 | — | — | 1 | 4.51 |
| CHEMBL90938 | — | — | 1 | 4.17 |
| CHEMBL78321 | — | — | 1 | - |
| CHEMBL73067 | — | — | 1 | - |
| CHEMBL73815 | — | — | 1 | - |
| CHEMBL92626 | — | — | 1 | - |
| CHEMBL327257 | — | — | 1 | - |
| CHEMBL93631 | — | — | 1 | - |
| CHEMBL328280 | — | — | 1 | - |
| CHEMBL90431 | — | — | 1 | - |
| CHEMBL93641 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL329024 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL328916 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL94033 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL328535 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL307180 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL93056 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL94277 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL93799 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL329214 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL329249 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL94076 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL93617 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL330583 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL90938 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL78321 | — | IC50 | = | 1077000.0 | nM | - |
| CHEMBL73067 | — | IC50 | = | 220000.0 | nM | - |
| CHEMBL73815 | — | IC50 | = | 540000.0 | nM | - |
| CHEMBL92626 | — | IC50 | = | 198000.0 | nM | - |
| CHEMBL327257 | — | IC50 | = | 164000.0 | nM | - |
| CHEMBL93631 | — | IC50 | = | 225000.0 | nM | - |
| CHEMBL328280 | — | IC50 | = | 200000.0 | nM | - |
| CHEMBL90431 | — | IC50 | = | 470000.0 | nM | - |
| CHEMBL93641 | — | IC50 | = | 304000.0 | nM | - |