Assay Detail
Functional
CHEMBL820326
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro cytotoxicity against hypoxic V79-379A cells determined by MTT assay in the presence of nitrogen
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cricetulus griseus |
| Cell Type | V79-379A |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Indolequinone antitumor agents: reductive activation and elimination from (5-methoxy-1-methyl-4,7-dioxoindol-3-yl)methyl derivatives and hypoxia-selective cytotoxicity in vitro.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.44 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL329024 | — | — | 1 | 7.40 |
| CHEMBL93056 | — | — | 1 | 7.40 |
| CHEMBL307180 | — | — | 1 | 7.40 |
| CHEMBL328535 | — | — | 1 | 7.40 |
| CHEMBL328916 | — | — | 1 | 7.30 |
| CHEMBL94033 | — | — | 1 | 7.10 |
| CHEMBL329214 | — | — | 1 | 6.70 |
| CHEMBL329249 | — | — | 1 | 6.52 |
| CHEMBL94076 | — | — | 1 | 6.52 |
| CHEMBL93799 | — | — | 1 | 6.18 |
| CHEMBL94277 | — | — | 1 | 6.16 |
| CHEMBL330583 | — | — | 1 | 6.07 |
| CHEMBL92626 | — | — | 1 | 6.00 |
| CHEMBL327257 | — | — | 1 | 5.70 |
| CHEMBL93617 | — | — | 1 | 5.60 |
| CHEMBL90938 | — | — | 1 | 5.52 |
| CHEMBL93641 | — | — | 1 | 4.48 |
| CHEMBL73815 | — | — | 1 | - |
| CHEMBL78321 | — | — | 1 | - |
| CHEMBL93631 | — | — | 1 | - |
| CHEMBL328280 | — | — | 1 | - |
| CHEMBL90431 | — | — | 1 | - |
| CHEMBL73067 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL329024 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL93056 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL307180 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL328535 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL328916 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL94033 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL329214 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL329249 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL94076 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL93799 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL94277 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL330583 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL92626 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL327257 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL93617 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL90938 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL93641 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL73815 | — | IC50 | = | 820000.0 | nM | - |
| CHEMBL78321 | — | IC50 | = | 285000.0 | nM | - |
| CHEMBL93631 | — | IC50 | = | 410000.0 | nM | - |
| CHEMBL328280 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL90431 | — | IC50 | = | 280000.0 | nM | - |
| CHEMBL73067 | — | IC50 | = | 240000.0 | nM | - |