Assay Detail
Functional
CHEMBL820381
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Effective concentration against Xenopus oocytes expressing human heart Na channel
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Oocyte |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of 6-heterocyclic-substituted purines as inactivation modifiers of cardiac sodium channels.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 5.91 | 7.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1907677 | — | — | 1 | 7.11 |
| CHEMBL313277 | — | — | 1 | 6.54 |
| CHEMBL87893 | — | — | 1 | 6.36 |
| CHEMBL1907673 | — | — | 1 | 6.35 |
| CHEMBL312861 | — | — | 1 | 6.05 |
| CHEMBL420045 | — | — | 1 | 6.05 |
| CHEMBL316270 | — | — | 1 | 6.04 |
| CHEMBL315998 | — | — | 1 | 5.99 |
| CHEMBL314661 | — | — | 1 | 5.90 |
| CHEMBL316248 | — | — | 1 | 5.90 |
| CHEMBL85548 | — | — | 1 | 5.80 |
| CHEMBL87178 | — | — | 1 | 5.71 |
| CHEMBL313247 | — | — | 1 | 5.70 |
| CHEMBL86348 | — | — | 1 | 5.68 |
| CHEMBL314639 | — | — | 1 | 5.64 |
| CHEMBL313458 | CARSATRIN | 2.0 | 1 | 5.64 |
| CHEMBL87286 | — | — | 1 | 5.57 |
| CHEMBL87085 | — | — | 1 | 5.55 |
| CHEMBL1907675 | — | — | 1 | 5.40 |
| CHEMBL1907676 | — | — | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1907677 | — | EC50 | = | 78.0 | nM | 7.11 |
| CHEMBL313277 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL87893 | — | EC50 | = | 433.0 | nM | 6.36 |
| CHEMBL1907673 | — | EC50 | = | 447.0 | nM | 6.35 |
| CHEMBL312861 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL420045 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL316270 | — | EC50 | = | 920.0 | nM | 6.04 |
| CHEMBL315998 | — | EC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL314661 | — | EC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL316248 | — | EC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL85548 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL87178 | — | EC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL313247 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL86348 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL314639 | — | EC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL313458 | CARSATRIN | EC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL87286 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL87085 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL1907675 | — | EC50 | = | 3990.0 | nM | 5.40 |
| CHEMBL1907676 | — | EC50 | = | 7260.0 | nM | 5.14 |