Assay Detail
Binding
CHEMBL820390
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of Voltage-gated sodium channel by the displacement of [3H]batrachotoxin A 20-alpha-benzoate in rat brain cerebral cortex synaptoneurosomes
25
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Sodium channel alpha subunits; brain (Types I, II, III) (CHEMBL2095171) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Comparative molecular field analysis of hydantoin binding to the neuronal voltage-dependent sodium channel.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 4.65 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL417155 | — | — | 1 | 5.30 |
| CHEMBL39043 | — | — | 1 | 5.30 |
| CHEMBL287713 | — | — | 1 | 5.05 |
| CHEMBL289499 | — | — | 1 | 4.89 |
| CHEMBL288505 | — | — | 1 | 4.41 |
| CHEMBL16 | PHENYTOIN | 4.0 | 1 | 4.40 |
| CHEMBL39889 | — | — | 1 | 4.24 |
| CHEMBL39326 | — | — | 1 | 4.24 |
| CHEMBL39247 | — | — | 1 | 4.02 |
| CHEMBL290090 | — | — | 1 | - |
| CHEMBL39126 | — | — | 2 | - |
| CHEMBL39810 | — | — | 1 | - |
| CHEMBL39377 | — | — | 1 | - |
| CHEMBL108 | CARBAMAZEPINE | 4.0 | 1 | - |
| CHEMBL38760 | — | — | 2 | - |
| CHEMBL289046 | — | — | 1 | - |
| CHEMBL288861 | — | — | 1 | - |
| CHEMBL289431 | — | — | 1 | - |
| CHEMBL290743 | — | — | 1 | - |
| CHEMBL38588 | — | — | 1 | - |
| CHEMBL39010 | — | — | 1 | - |
| CHEMBL38675 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39043 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL417155 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL287713 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL289499 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL288505 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL16 | PHENYTOIN | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL39889 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL39326 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL39247 | — | IC50 | = | 95000.0 | nM | 4.02 |
| CHEMBL290090 | — | IC50 | = | 251000.0 | nM | - |
| CHEMBL39126 | — | IC50 | = | 427000.0 | nM | - |
| CHEMBL39810 | — | IC50 | = | 285000.0 | nM | - |
| CHEMBL39377 | — | IC50 | = | 251000.0 | nM | - |
| CHEMBL108 | CARBAMAZEPINE | IC50 | = | 131000.0 | nM | - |
| CHEMBL38760 | — | IC50 | = | 225000.0 | nM | - |
| CHEMBL39126 | — | IC50 | = | 427000.0 | nM | - |
| CHEMBL289046 | — | IC50 | = | 851000.0 | nM | - |
| CHEMBL288861 | — | IC50 | = | 162000.0 | nM | - |
| CHEMBL38675 | — | IC50 | = | 700000.0 | nM | - |
| CHEMBL289431 | — | IC50 | = | 2112000.0 | nM | - |
| CHEMBL290743 | — | IC50 | = | 250000.0 | nM | - |
| CHEMBL38760 | — | IC50 | = | 225000.0 | nM | - |
| CHEMBL38588 | — | IC50 | = | 720000.0 | nM | - |
| CHEMBL39010 | — | IC50 | = | 103000.0 | nM | - |
| CHEMBL38675 | — | IC50 | = | 700000.0 | nM | - |